cobrapy

Quick Review

Exceptional skill for constraint-based metabolic modeling. The description clearly conveys the skill's purpose for COBRA methods. SKILL.md is comprehensive with 10 well-organized capability sections covering model I/O, FBA, FVA, gene knockouts, flux sampling, media optimization, and model building. Each section provides concrete code examples with comments. Five practical workflows demonstrate end-to-end tasks. Key concepts and best practices sections add valuable context. The structure is logical with clear subsections and an index to reference files. High novelty: metabolic modeling requires specialized domain knowledge, complex constraint optimization, and understanding of systems biology concepts that would be inefficient for a CLI agent to replicate from scratch. Minor point: SKILL.md is detailed and long, but given the complexity of the domain and number of distinct capabilities, the length is justified and well-organized rather than cluttered.