NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.
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Exceptional genomics analysis skill with comprehensive coverage of deepTools NGS analysis workflows. The SKILL.md provides crystal-clear guidance for BAM/bigWig conversion, QC, and visualization tasks with excellent structure separating overview from detailed references. Strong task knowledge through workflow generators, validation scripts, and extensive reference documentation covering tools, normalization methods, and genome sizes. The skill demonstrates high novelty—orchestrating complex multi-step NGS analysis pipelines (QC→normalization→visualization) that would require substantial token investment for a CLI agent to piece together correctly. Minor improvement possible in making the initial description slightly more specific about when to invoke this vs. general bioinformatics tools, but overall this is a production-ready, well-documented skill that meaningfully reduces cost for genomics analysis workflows.
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