pubchem-database

Quick Review

Excellent comprehensive skill for PubChem cheminformatics querying. The description is crystal clear and actionable for CLI invocation. Task knowledge is outstanding with extensive code examples covering search, property retrieval, similarity/substructure searches, bioactivity queries, and common workflows. Structure is very good - SKILL.md provides detailed coverage while cleanly delegating specialized functions to helper scripts and comprehensive API details to references. The skill demonstrates strong novelty by providing a high-level interface to a complex 110M+ compound database with specialized cheminformatics operations (similarity searches, substructure matching, bioactivity data) that would be token-intensive and error-prone for a CLI agent to implement from scratch. Minor point: SKILL.md is quite detailed (could be slightly more concise), but this is appropriate given the complexity of the domain. Rate limiting guidance and error handling patterns add significant practical value.