pysam

Quick Review

Excellent bioinformatics skill with comprehensive coverage of pysam's genomic file processing capabilities. The SKILL.md provides clear, actionable guidance with strong quick-start examples and well-organized references for alignment, variant, and sequence file operations. The description is sufficiently detailed for CLI invocation, covering when to use the skill and core operations. Task knowledge is outstanding with referenced documentation for all major workflows. Structure is exemplary—concise main file with detailed references properly separated. Novelty is strong: genomic file manipulation with coordinate systems, indexing requirements, and multi-format integration would consume significant tokens and require specialized domain knowledge for a CLI agent. Minor room for improvement in the description's specificity about edge cases, but overall this is a highly practical, well-documented skill that meaningfully reduces complexity for NGS data processing tasks.